[Proteintech] 신경 퇴행성 질환 연관 TDP-43 Protein 관련 제품들

TDP-43 Protein이란?

TARDBP 또는 TDP-43로도 알려진 43kDa의 TAR(Transactivation response) DNA 결합 단백질은 HIV-1 바이러스의 TAR DNA 요소에 결합하는 transcriptional inactivator로서 처음 분리되었습니다. Neumann et al. (2006) 논문에서 병리학적 TDP-43으로 알려진 TARDBP의 hyperphosphorylated, ubiquitinated 및 cleaved form 형태들는 근위축성 측색 경화증(ALS)을 특징짓는 tau-negative 및 ubiquitin-positive 포함물의 주요 구성 요소이며 전측두엽 변성 (FTLD-U)의 가장 일반적인 병리학적 하위 유형이라는 것을 발견했습니다.

Proteintech에서는 TDP-43 Protein과 관련있는 다양한 Antibodies, ELISA Kit, IHC Kit를 판매하고 있습니다. TDP-43 외 Neuroscience 관련 antibodies는 하단의 catalogue 파일을 참고해주시기 바랍니다.

TDP-43_antibody

Figure 1. Immunohistochemical analysis of healthy brain tissue (A) and patients with accumulated TDP43 in hippocampus (B,C; green arrows, TDP43 accumulations) using anti-TDP43 (80001-1-RR) at 1:1000 dilution. Images courtesy of Pete Nelson, MD PhD, University of Kentucky Sanders-Brown

Beta_Tubulin_TDP43

Figure 2. Western blot analysis of Hela (lane 1), K562 (lane 2), Neuro2a (lane 3), and C6 (lane 4) cells using anti-TDP43 (80001-1-RR) and beta tubulin(10094-1-AP) antibodies at 1:1000 dilution.

TDP-43_antibody

Figure 3. Immunohistochemical analysis of glioma tissue using anti-TDP43 (80001-1-RR) at 1:1000 dilution.

TDP-43_antibody

Figure 4. Immunofluorescent analysis of HepG2 cells using anti-TDP43 (80002-1-RR) at dilution of 1:500 (Green) and CoraLite555-Phalloidin (Red).

Related Products

TDP-43 Antibodies
Catalog No. Target Type Applications Publications
10782-2-AP TDP-43 (N-terminal), KD/KO Validated Rabbit Poly WB, RIP, Immunoelectron, IF, IHC, IP, FC, CoIP, ChIP, ELISA 1205
12892-1-AP TDP-43 (C-terminal), KD/KO Validated Rabbit Poly WB, IF, IHC, IP, ELISA 130
18280-1-AP TDP-43 (full length) Rabbit Poly WB, IF, IHC, IP, FC, ELISA 5
22309-1-AP phospho(409/410)-TDP43 Rabbit Poly WB, IF, IHC, ELISA 47
60019-2-Ig TDP-43 (human specific) Mouse Mono WB, IHC, IP, FC, CoIP, ELISA 72
66079-1-Ig phospho(403/404)-TDP43 Mouse Mono WB, FC, ELISA 4
66318-1-Ig phospho(409/410)-TDP43 Mouse Mono WB, IF, ELISA 6
66734-1-Ig TDP-43 Mouse Mono WB, IF, IHC, FC, ELISA 4
67345-1-Ig TDP-43 (C-terminal) Mouse Mono WB, IF, IHC, FC, ELISA 1
80001-1-RR TDP-43 (N-terminal), KD/KO Validated Rabbit Rec WB, IHC, ELISA  
80002-1-RR TDP-43 (N-terminal) Rabbit Rec IF, FC, ELISA  
80007-1-RR phospho(409/410)-TDP43 Rabbit Rec WB, IHC, ELISA 1
CL488-10782 CoraLite488-conjugated TDP-43 Rabbit Poly IF, FC (Intra)  
CL488-12892 CoraLite488-conjugated TDP-43 (C-terminal) Mouse Mono IF, FC (Intra)  
CL488-67345 CoraLite488-conjugated TDP-43 (C-terminal) Mouse Mono IF  
CL488-80002 CoraLite488-conjugated TDP-43 Rabbit Rec IF, FC (Intra)  
CL594-12892 CoraLite594-conjugated TDP-43 (C-terminal) Rabbit Poly IF, FC (Intra)  
CL594-80002 CoraLite594-conjugated TDP-43 Rabbit Rec IF, FC (Intra)  
TDP-43 ELISA Kits
Catalog No. Target Type Sample type
KE00005 Human TDP-43 ELISA Kit Sandwich ELISA Serum, plasma
KE00009 Human TDP-43 ELISA Kit Sandwich ELISA Human cerebrospinal fluid, cell lysates
TDP-43 IHC Kit
Catalog No. Target Reactivity Sample type
KHC0001 IHCeasy TDP-43 Ready-To-Use IHC Kit Human, Rat, Mouse FFPE Tissue
Koram-Contact_number.