Name of miRNA |
miRNA expression
pattern |
Target Genes
affected by miRNA |
miRNA Role in Invasion-Metastasis Cascade |
miR-142-3p |
UP |
ITGAV, WASL, RAC1, CFL2 |
Cancer cell invasiveness inhibition |
miR-495 |
UP |
JAM-A |
Cancer cell migration |
miR-10b |
UP |
HOXD10 |
Cell migration and invasion |
miR-373 |
UP |
ITGA2 |
Cell migration, metastasis |
miR-103/107 |
UP |
DICER1 |
EMT, cell migration, metastasis |
miR-661 |
UP |
NECTIN1, STARD10 |
EMT, invasion |
miR-221/222 |
UP |
TRPS1 |
EMT, invasion and migration (basal-like BC) |
miR-23a |
UP |
CDH1 |
EMT, metastasis |
miR-374a |
UP |
WIF1, PTEN, WNT5A |
EMT, metastasis |
miR-22 |
UP |
TET1-3 |
EMT, stemness |
miR-155 |
UP |
RHOA |
EMT, tight junction dissolution, migration and invasion |
miR-191/425 |
UP |
DICER1 |
Invasion and metastasis |
miR-221 |
UP |
CDH1 |
Invasion and metastasis |
miR-221 |
UP |
DNMT3B |
Pluripotency and stemness |
miR-21 |
UP |
TPM1 |
Tumor growth and malignant phenotype |
miR-145 |
DOWN |
JAM-A |
Cancer cell motility inhibition |
miR-145 |
DOWN |
JAM-A |
Cancer cell motility inhibition |
miR-198 |
DOWN |
CDCP1 |
Cell adhesion and migration inhibition |
miR-154 |
DOWN |
ADAM9 |
Cell migration and invasion inhibition |
miR-200a |
DOWN |
CX43 |
Cell migration and metastasis inhibition |
miR-206 |
DOWN |
CX43 |
Cell migration and metastasis inhibition |
miR-181a-5p |
DOWN |
MMP14 |
Cell migration inhibition |
miR-539 |
DOWN |
LAMA4 |
Cell migration inhibition (TNBC) |
miR-7 |
DOWN |
PAK1 |
Cell motility and invasiveness inhibition |
miR-494 |
DOWN |
PAK1 |
Clonogenic ability and cell migration, invasion and metastasis inhibition |
miR-29b |
DOWN |
VEGFA, ANGPTL4, PDGF, LOX, MMP9 |
EMC re-modeling and metastasis inhibition |
miR-200c |
DOWN |
ZEB1, TKS5, MYLK |
EMT and invadopodia forming inhibition |
miR-153 |
DOWN |
MTDH |
EMT and invasion inhibition |
miR-124 |
DOWN |
SNAI2 |
EMT and metastasis inhibition |
miR-200b |
DOWN |
FERMT2 |
EMT and metastasis inhibition |
miR-34 |
DOWN |
SNAI1 |
EMT inhibition |
miR-205 |
DOWN |
ZEB1, ZEB2 |
EMT inhibition |
miR-375 |
DOWN |
SHOX2 |
EMT inhibition |
miR-506 |
DOWN |
SNAI2, VIM, CD151 |
EMT, adhesion, invasion, and migration inhibition |
miR-30a |
DOWN |
ZEB2 |
EMT, invasion and distal spreading inhibition (TNBC) |
miR-203 |
DOWN |
SNAI1 |
EMT, invasion and metastasis inhibition |
miR-34c |
DOWN |
NOTCH4 |
EMT, migration and self-renewal inhibition |
miR-320 |
DOWN |
ETS2 |
Inhibition of tumor micro-environment re-programming |
miR-200 cluster |
DOWN |
WAVE3 |
Invasion and cell migration inhibition |
miR-33a |
DOWN |
ADAM9 |
Invasion and metastasis inhibition |
miR-193b |
DOWN |
uPA |
Invasion and metastasis inhibition |
miR-335 |
DOWN |
TNC, SOX4 |
Invasion and metastasis inhibition |
miR-720 |
DOWN |
TWIST1 |
Invasion and metastasis inhibition |
miR-126 |
DOWN |
ADAM9 |
Invasion inhibition |
miR-181a |
DOWN |
uPA |
Invasion inhibition |
miR-193a/b |
DOWN |
uPA |
Invasion inhibition |
miR-221/222 |
DOWN |
ITGB4, STAT5A, ADAM17 |
Invasion inhibition (luminal BC) |
miR-224 |
DOWN |
CDC42, CXCR4 |
Invasion, metastasis inhibition |
miR-31 |
DOWN |
WAVE3 |
Invasive phenotype reduction |
miR-126 |
DOWN |
CXCL12 |
Metastasis inhibition |
miR-124a |
DOWN |
|
Proliferation and metastasis inhibition |
miR-708 |
DOWN |
LSD1 |
Proliferation, invasion inhibition |
miR-30 |
DOWN |
UBC9 |
Self-renewal |
let-7 |
DOWN |
H-RAS, HMGA2 |
Self-renewal, stemness |
miR-590 |
DOWN |
SOX2 |
Stemness |
miR-140 |
DOWN |
SOX2 |
Stemness, self-renewal |
miR-183 cluster |
DOWN |
BMI1 |
Stemness, self-renewal |