2022년 Cayman의 가장 인기 있는 ELISA Kit 상위 10개를 소개합니다. Steroid hormone ELISA가 대부분을 차지하며, lipid metabolite와 cyclic nucleotide second messenger ELISA 제품들이 그 뒤를 따르고 있습니다.
1. 2’3′-cGAMP ELISA Kit
2’3′-cGAMP is a second messenger produced from ATP and GTP by cyclic GMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of dsDNA.1–3 It contains a non-canonical 2’5′-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes), resulting in IRF3 phosphorylation and the production of type I interferons.3,4 Activation of cGAS and the production of 2’3′-cGAMP are important in host defense but also may play role in autoimmune or inflammatory diseases.5
2. 8-Isoprostane ELISA Kit
8-Isoprostane is produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.6,7 8-Isoprostane is present in human plasma and urine and levels increase with age and under conditions of oxidative stress.6,8
Related Items: TBARS Assay Kit, Lipid Hydroperoxide (LPO) Assay Kit, Superoxide Dismutase Assay Kit, 8-Isoprostane Express ELISA Kit, STAT-8-Isoprostane ELISA Kit, 8-Isoprostane Affinity Purification Kit
4. Cortisol ELISA Kit
Cortisol is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).10 Cortisol is secreted in a circadian manner and peaks just prior to waking in the morning. Cortisol levels increase with age and are often elevated in various disease states, including major depressive disorder, certain forms of hypertension, and AIDS.11-13 Cortisol also promotes adipocyte differentiation.14,15
5. Citrullinated Histone H3 (Clone 11D3) ELISA Kit
Histone H3 is citrullinated by PAD4 during epigenetic chromatin remodeling and neutrophil extracellular trap (NET) formation.16-19 Failure to clear citrullinated proteins and NET components can result in autoantibodies and anti-citrullinated protein antibodies, which are associated with several human diseases including rheumatoid arthritis, systemic lupus erythematosus, Alzheimer’s disease, and multiple sclerosis.20 Citrullinated histone H3 can also be used as a functional readout of pharmacological PAD inhibition.
6. Cyclic GMP ELISA Kit
Guanosine 3′,5′-cyclic monophosphate (cyclic GMP or cGMP) is a key intracellular second messenger that transduces cellular signaling events to cGMP-gated channels, cGMP-dependent kinases, and cGMP-regulated phosphodiesterases in response to a variety of hormones, autacoids, and drugs.21,22 The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate guanylate cyclase at the cell surface or intracellular activation of soluble guanylate cyclase by nitric oxide.23,24
Related Item: Cyclic AMP ELISA Kit
7. Estradiol ELISA Kit
Estradiol is a steroid hormone produced from testosterone via the aromatase system in the granulosa cells of ovarian follicles.25,26 It is instrumental in the development of secondary sex characteristics at puberty and in the menstrual cycle.27-29 Estradiol is metabolized into estrone by 17β-hydroxysteroid dehydrogenase 2 and hydroxylated metabolites such as estriol, as well as glucuronidated and sulfonated metabolites, which are excreted in the urine and feces.30
8. Human Therapeutic IgG1 ELISA Kit
Cayman’s Human Therapeutic IgG1 ELISA Kit distinguishes experimentally introduced human IgG from endogenous monkey IgG for use in the pharmacokinetic analysis of therapeutic human antibodies in monkeys.
9. Prostaglandin E2 ELISA Kit – Monoclonal
Prostaglandin E2 (PGE2) is an eicosanoid formed by COX-mediated metabolism of arachidonic acid.31 The effects of PGE2 are mediated by at least four distinct receptors designated EP1, EP2, EP3, and EP4. PGE2 has diverse roles in inflammation, immune modulation, preservation of renal and bone homeostasis, gastric mucosal integrity, fertility, and parturition.32-35
10. Testosterone ELISA Kit
Testosterone is the primary androgenic steroid in mammals.36 It plays a major role in the growth and function of many reproductive and non-reproductive tissues and organs including muscle, liver, and brain, directing the development of the male phenotype during embryogenesis and at puberty.
Cayman is proud to have been selected as the 2022 Bioz Stars All Star™ in the ELISA category.