[Cellecta] T & B cell Receptor Repertoires 프로파일링 분석- DriverMap Adaptive Immune Receptor (AIR) Profiling Assay

DriverMap Adaptive Immune Receptor (AIR) TCR-BCR Profiling Assay

Cellecta “DriverMap^TM AIR Profiling Assay“는 T-cell receptor (TCR)와 B-cell receptor (BCR)의 CDR3 repertoire 프로파일링을 multiplex PCR-NGS technology를 사용하여 빠르고 간편하게 분석할 수 있는 assay kit입니다.

Celleta DriverMap^TM AIR Profiling Assay는 기존의 타브랜드 제품과 달리 TCR과 BCR의 모든 chain을 (TRA, TRB, TRG & TRD/BCR -IGH, IGK & IKL) single tube & single-day로 분석할 수 있습니다.

모든 종류의 immune sample 에서 분석 가능 ( whole blood, PBMC, cancer biopsies, tissue samples, FFPE or dried blood microsamples 등)
RNA 추출 과정 없이 immune cells (또는 sample)에서 직접 분석 가능 (e.g.,100-50,000 FACS-sorted cells)
Unique Molecular Identifiers (UMIs)으로 정확하고 정량적인 AIR clonotypes 분석 가능.
Pseudogenes, ORFs 또는 misarranged genes의 증폭 없이 functional TCR/BCR mRNA만 검출 가능

Applications of BCR sequencing
- Identify broadly neutralizing antibodies (BNAbs) and map Ig-seq datasets to known antibody structures for antibody and vaccine development.
- Track B-cell migration and development patterns
- Find clinical markers of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and cancers (e.g. B-cell lymphoma)
- Contrast naïve and antigenically challenged datasets for understanding antibody maturation

Applications of TCR sequencing
- Track T-cell clonality and diversity for mechanism of action of immune checkpoint inhibitors for immunotherapies
- Assess TCR overlap between repertoires to define spatial and temporal heterogeneity of the anti-tumoral immune response
- Analyze TCR sequence and structure to annotate antigenic specificity for developing personalized cellular immunotherapies

Products

Cat#	Kit Name
DMAIR-HTBR-24	New DriverMap™ AIR TCR–BCR Profiling Kit (Human RNA) 24 multiplex
DMAIR-HTBR-96	New DriverMap™ AIR TCR–BCR Profiling Kit (Human RNA) 96 multiplex
DMAIR-HTR-24	New DriverMap™ AIR TCR Profiling Kit (Human RNA) 24 multiplex
DMAIR-HTR-96	New DriverMap™ AIR TCR Profiling Kit (Human RNA) 96 multiplex
DMAIR-HBR-24	New DriverMap™ AIR BCR Profiling Kit (Human RNA) 24 multiplex
DMAIR-HBR-96	New DriverMap™ AIR BCR Profiling Kit (Human RNA) 96 multiplex