DriverMap Adaptive Immune Receptor (AIR) TCR-BCR Profiling Assay
Cellecta “DriverMapTM AIR Profiling Assay“는 T-cell receptor (TCR)와 B-cell receptor (BCR)의 CDR3 repertoire 프로파일링을 multiplex PCR-NGS technology를 사용하여 빠르고 간편하게 분석할 수 있는 assay kit입니다.
Celleta DriverMapTM AIR Profiling Assay는 기존의 타브랜드 제품과 달리 TCR과 BCR의 모든 chain을 (TRA, TRB, TRG & TRD/BCR -IGH, IGK & IKL) single tube & single-day로 분석할 수 있습니다.
- 다양한 종류의 immune sample 분석 가능 (whole blood, PBMC, cancer biopsies, tissue samples, FFPE or dried blood micro samples 등)
- RNA 추출 과정 없이 immune cells (또는 sample)에서 직접 분석 가능 (e.g.,100-50,000 FACS-sorted cells)
- Unique Molecular Identifiers (UMIs)으로 정확하고 정량적인 AIR clonotypes 분석 가능.
- Pseudo-genes, ORFs 또는 misarranged genes의 증폭 없이 functional TCR/BCR mRNA만 검출 가능
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Applications of BCR sequencing
- Identify broadly neutralizing antibodies (BNAbs) and map Ig-seq datasets to known antibody structures for antibody and vaccine development.
- Track B-cell migration and development patterns
- Find clinical markers of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and cancers (e.g. B-cell lymphoma)
- Contrast naïve and antigenically challenged datasets for understanding antibody maturation
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Applications of TCR sequencing
- Track T-cell clonality and diversity for mechanism of action of immune checkpoint inhibitors for immunotherapies
- Assess TCR overlap between repertoires to define spatial and temporal heterogeneity of the anti-tumoral immune response
- Analyze TCR sequence and structure to annotate antigenic specificity for developing personalized cellular immunotherapies
- 모든 DriverMap AIR TCR/BCR profiling 제품의 24-sample size kits에만 적용됩니다.
- 구매자가 아닌 실험실 기준으로 각 cat# 당 1회만 적용됩니다. (One of each kit type per lab – one discount per catalog number)
- 주문 시 대리점/지사에 프로모션 코드 “AIR24-2401”를 알려주셔야 할인이 적용됩니다.
- Limited-time pricing 2024년 3월 25일 (기간 내 접수된 주문만 할인 적용됩니다. 서두르세요 !! )
Cat # |
Description |
DMAIR-HTBR-24 |
DriverMap™ AIR TCR–BCR Profiling Kit (Human RNA) |
DMAIR-HTBR-F-24 |
DriverMap™ AIR TCR–BCR Full-length Profiling Kit (Human RNA) |
DMAIR-HTR-24 |
DriverMap™ AIR TCR Profiling Kit (Human RNA) |
DMAIR-HTR-F-24 |
DriverMap™ AIR TCR Full-length Profiling Kit (Human RNA) |
DMAIR-HBR-24 |
DriverMap™ AIR BCR Profiling Kit (Human RNA) |
DMAIR-HBR-F-24 |
DriverMap™ AIR BCR Full-length Profiling Kit (Human RNA) |
DMAIR-HTD-24 |
DriverMap™ AIR TCR Profiling Kit (Human DNA) |
DMAIR-HBD-24 |
DriverMap™ AIR BCR Profiling Kit (Human DNA) |
DMAIR-MTBR-24 |
DriverMap™ AIR TCR-BCR Profiling Kit (Mouse RNA) |
DMAIR-MTR-24 |
DriverMap™ AIR TCR Profiling Kit (Mouse RNA) |
DMAIR-MBR-24 |
DriverMap™ AIR BCR Profiling Kit (Mouse RNA) |